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We also appreciate the question as to why our experiments with SWI/SNF were not conducted on a variety of templates with the Gal4 binding site separated at a range of distances from the 601NPE, as were done with ISWI experiments.
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Furthermore, we discovered an adjacent, second miR-122 binding site, separated from the first by a highly conserved 14-nucleotide sequence.
QRE is a bipartite binding site separated by less than 20 base pairs.
The MMP-1 promoter contains at least two proximal AP-1 binding sites, separated by less than 100 nucleotides.
Many simple motif extraction algorithms have been proposed primarily for extracting the transcription factor binding sites, where each motif consists of a unique binding site [ 4- 10] or two binding sites separated by a fixed number of gaps [ 11- 13].
Both α-actinin and filamin have two actin-binding sites separated by a relatively flexible molecular arm.
Lac repressor binding site was separated from the 601NPE by 10 bp.
The free energy landscape showed favorable free energies at the periplasmic opening and the internal binding site, which were separated by a 20 ± 5 kJ/mol barrier (Fig. 5A,B) and an associated binding free energy of -24 ± 10 kJ/mol, which is in excellent agreement with the experimental binding free energy of −23 kJ/mol24.
PLG and collagen type IV competed with LipL32 protein for the same binding site, whereas separate binding sites were observed for plasma fibronectin.
Typically NFAT- and AP-1-binding sites are separated by seven or less nucleotides.
a, 2mFo−DFc electron density map (blue mesh) of residues around the methylguanidinium binding site at 1σ. b, Overlay of guanidinium binding site (green) and methylguanidinium binding site (orange).
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CEO of Professional Science Editing for Scientists @ prosciediting.com