Sentence examples for binding site rather than from inspiring English sources
b | Isocitrate dehydrogenase 1 (IDH1); the predicted druggable cavity is the α-ketoglutarate binding site rather than the cofactor NADP binding site; a somatic, dominant change-of-function mutation in this gene is implicated in type II glioma, glioblastoma and leukaemia.
We hypothesize that they target the nucleotide (ATP) binding site rather than the expected cytoplasm-accessible pocket.
This indicates that long-range intramolecular interactions are involved in the formation of the CFH and CFHR-1 binding site rather than linear peptide sequences (Fig. 3A).
Additionally, G 319 T is immediately adjacent to the canonical -35 sigma factor binding site, rather than within the site, so the effect of nearby substitutions can be observed.
Hence, the heat observed upon addition of CpxI(26-83) to SCΔ60 blocked wito CpxI(27-134) ariSCΔ60rom completion of the titration of the central helix blocked site, rather than from interactions involving the accessory helix.
The pH-dependent transport activity of PaNhaP suggests a self-regulatory mechanism for the binding site rather than regulation by a separate pH sensor as proposed for EcNhaA (Herz et al., 2010; Diab et al., 2011; Schushan et al., 2012).
This was rationalized by a possibly better accessibility of the antigen binding sites rather than a consequence of specific surface increase.
Two inhibitor molecules are bound in the central RNA binding cavity of RNase A exploiting interactions with residues from peripheral binding sites rather than from the active site of the enzyme.
Hence, sequence similarity in binding sites, rather than in the entire protein, may be a more reliable predictor of functional similarity.
(40) This method provides a direct measurement of available binding sites, rather than the number of conjugated proteins.
