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Identification of the SH3 binding site provides a basis for understanding the interaction between the SH3 domains and their targets.
This binding site provides a mechanism for the incorporation of urokinase into the cell membrane.
Although PglB is a prokaryotic homologue that modifies a slightly different consensus sequence, its peptide binding site provides a structural basis for the mammalian OST co- and post-translational N-glycosylation kinetics of the different NXS consensus sites.
The structure of the p300/acetonyl-CoA and p300/CoA complexes with two PEG moieties bound proximal to the cofactor binding site provides a more rational approach to developing potent and selective small molecule p300 inhibitors.
Consequently, the composite LysM1 LysM3 binding site provides a single binding event with ultra-high (pM) affinity for chitin binding, the highest chitin-binding affinity described in nature, which is extremely competent to sequester chitin oligosaccharides.
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This novel intracellular site partially overlaps with the G protein and β-arrestin binding site, providing a new manner of pharmacological intervention.
Therefore, the conformational space constraints imposed by the hemagglutinin receptor binding site provide a characteristic signature that could be a useful tool for the surveillance of human adaptation of other (such as H7N9 and H5N1) deadly influenza viruses.
In addition, it might show that WFA binding, indicating the presence of highly charged anionic binding sites, provides a signature for the neuroprotective properties of PNs.
Turnover of transcription factor binding sites provides a simple model whereby the function of distantly related promoters can be conserved while their sequences diverge (Hancock et al. 1999; Ludwig et al. 2000; Dermitzakis and Clark 2002).
Various miRNA binding sites provide a number of choices which not only meet different needs under various processes but also avoid unwanted cross-reactions.
It is suggested here that the Tra2-ISS binding sites provide a discriminative feature for the tra and dsx pre-mRNAs regions involved in sex-specific splicing regulation.
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