Sentence examples for binding site plays a from inspiring English sources

We asked whether methylation of the potential c-Myc binding site plays a role in the regulation of MYCT1.

Furthermore, Yamasaki et al. (2003) have shown that the atypical Grb2 binding site plays a dominant role in the Gads/Grb2-mediated recruitment of Gab2 to the LAT signalling complex in the lipid rafts of T lymphocytes [ 41].

We conclude that the CUX1 consensus binding site plays a role in the recruitment of CUX1 at specific genomic locations, but the presence of a consensus site is not sufficient.

In contrast, the P4 residue, Phe, makes many contacts with the enzyme, and the observation that the chromogenic peptide Ac-FQLQ pNA is cleaved but that Ac-QLQ pNA is not suggests that the S4 binding site plays a very important role in productive substrate binding.

These findings that the presence of a water molecule in the hydrophobic binding site plays an important role are a step towards a quantitative understanding of the character of bridge water in enzyme-inhibitor binding.

We found that Sp1 binding sites are important both for basal and hyperosmolarity-induced promoter activities, whereas the NF-κB binding site plays an important role in the hyperosmolarity-induced promoter activity.

Since proteins carry out their functions through interactions with other molecules, accurately identifying the protein-ligand binding site plays an important role in protein functional annotation and rational drug discovery.

The target protein and the characteristics of its binding site play a major role.

It remains unclear whether a subset of CTCF binding sites plays a functional role in establishing/maintaining chromatin topological domains.

To determine whether the A11-binding site plays a functional role in protein folding, we first investigated the effects of A11 antibody on GroEL/ES (GroE -assisted firefly luciferase refoldinGroE -assisted

Many transcription factor binding sites are highly conserved throughout the sequences and the discovery of the location of such binding sites plays an important role in understanding gene interaction and gene regulation.