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Of the 29 pairs, 17 have a miRNA binding site on only one of the two duplicated paralogs (Additional file 2) and other 12 have the same miRNA binding site on both duplicated paralogs (Additional file 3).
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The basic algorithm described above assumes that there is one and only one binding site on each sequence, which is certainly not always true.
According to this hypothesis, the full GE binding site on RNAP includes not only the genetically-defined GE target, but also the full, or nearly the full, active-center i and i+1 sites; and GE bound to its target would be positioned to interfere directly, through steric clash, with function of the i and i+1 sites and/or Mg2+(I).
However, in our gene regulatory system, the number of transcription factors for the regulating genes is mostly one, and all the transcription factors have only one binding site on the promoter region.
Several models of muscle contraction assume that only one binding site on the actin filament is within reach for binding of a given myosin head.
Low efficiency may be explained by very low expression of TAp63 in FaDu cells by western blot and only one binding site on TAp63 promoter by WT1 protein by ChIP/PCR.
Dynein and KAP3 share the same binding site on p150Glued, and so p150Glued binds to only one of them at a time and thereby activates transport in only one direction.
These results suggest that a high load stabilizes the interaction of each MotPS stator unit with its binding site on the motor and that only a small decrease in the load induces rapid dissociation of several MotPS stators from the motor.
In Bax, the C-terminal α-helix occupies a similar position to the BH3-only binding site on pro-survival proteins and blocks the groove.
There is only one established drug binding site on sodium channels.
Here we describe a series of inhibitors, which occupy only the central binding site on CaS100B (site 2) through a covalent attachment to Cys84.
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