Sentence examples for binding site of this from inspiring English sources
The data suggest that the different kinetics of activation of myosin light chain kinase by CaM23 and CaMIM are not due to differences in the ability of the activators to bind to the calmodulin binding site of this enzyme.
This structure reveals the chemical environment or ' pharmacophore' presented by the ligand binding site of this Aβ segment, that is, orange G binds to stacked β-sheets of Aβ.
The binding site of this enzyme possesses two main subpockets: the catalytic anion-binding site and the hydrophobic specificity pocket.
We have analyzed the binding site of this G protein-coupled receptor using ligand design, site-directed mutagenesis, and homology modeling based on rhodopsin.
With the aim of efficiently identifying a new class of orally available inhibitors of the ATP binding site of this protein, we conducted fragment screening and virtual screening in parallel against Hsp90.
To our knowledge, this is the first molecular modelling study conducted with the catalytic binding site of this crystal structure.
Third, the pharmacophore subsets of the query molecule could be restricted to contain only atoms that are known to make interactions with the protein binding site of the biological target (this requires a reference structure of the protein-ligand complex).
Between the intI gene and the attC site, we found a small segment (between 1344230 and 1344237 bp) of the same sequence (GTTAGGT) as the R' binding site in the predicted attC site of T. brennaborense, consistent with this segment being the R binding site of the attI site for this integron.
Thus, if the RT primer binds to another sequence than the miRNA of interest, this will lead to incorporation of the binding site of the TaqMan probe and this unspecific amplicon will be indistinguishable from the desired PCR product.
We designed the extensions to contain alanine residues since alanine lacks an extended side chain that may offer extra interactions with the binding site of the enzyme and complicate this analysis.
The amino acids composing the binding site of the mammalian cyclooxygenases considered in this study (Table 1), were described with five amino acid extended principal property scales (5 z-scales) [48].
