Sentence examples for binding site of such from inspiring English sources

Ultra-low-dose opioid antagonists enhance opioid analgesia and reduce analgesic tolerance and dependence by preventing a G protein coupling switch (Gi/o to Gs) by the mu opioid receptor (MOR), although the binding site of such ultra-low-dose opioid antagonists was previously unknown.

The oligonucleotides such as penta- and hexanucleotides often provide the binding sites of proteins such as transcription factors.

The recent advances in the high-throughput techniques for identifying in vivo binding sites of TFs such as ChIP-on-chip/ChIP-PET have enabled genome-wide mapping of binding sites for TFs such as OCT4, SOX2, NANOG, c-MYC and SUZ12 [ 31- 33].

In addition to MA, other FTO inhibitors with special structural binding site of FTO were identified, such as N- 5-chloro-2,4-dihydroxyphenyl -1-phenylcyclobutanecarboxamide N- 5-chloro-2,4-dihydroxyphenyl -1-phenylcyclobutanecarboxamide N- 5-chloro-2,4-dihydroxyphenyl -1-phenylcyclobutanecarboxamide N- 5-chloro-2,4-dihydroxyphenyl -1-phenylcyclobutanecarboxamide N- 5-chloro-2,4-dihydroxyphenyl -1-phenylcyclobutanecarboxamide N- 5-chloro-2,4-dihydroxyphenyl -1-phenylcyclobutanecarboxamide N- 5-chloro-2,4-dihydroxyphenyl -1-phenylcyclobutanecarboxamide

In addition, the BIR domain has a regulatory function as the binding site of several IAP antagonists such as SMAC/Diablo and HtrA2.

The -318 TRE region is important as a c-FOS responsive element for inducing enhanced expression of FOSL-1 [ 29, 58] and serves as the binding site of AP-1 proteins such as c-JUN and JUND [ 59].

Since the synthetic substrate is common to all the three isozymes, the conformation of the binding site for such clones is likely to be a shared one.

At around the same time, a series of isoxazolidine-containing molecules named iTADs were described that bind in the same binding site of KIX as transactivation domains of proteins such as MLL, c-Jun, and Tat.

Therefore, ERα is clearly a good candidate to explain the regulation of ELOVL6 expression through dynamic epigenetic changes in the binding site of known regulators of ELOVL6 gene, such as SREBF1 and SP1.

By binding CcO through the respective His-tag, the former orients CcO such that the binding site of Cc is exposed to the bulk solution.

This motif has been recently shown to be a functional sequence that is used to target the ribosome binding sites of target mRNAs such as RNAIII [84] and RsaE [26].