Sentence examples for binding site of protein from inspiring English sources
We study the human serum albumin (HSA) protein-CuO nanoparticle interaction to identify the specific binding site of protein with CuO nanoparticles by molecular docking and compared it with HSA-TiO2 nanoparticle interaction.
Various analogs of flavins, 5-deazaflavins, and flavin-5-oxides were docked into the binding site of protein tyrosine kinase pp60c-src, and some of them were assayed for their potential antitumor and PKC (protein kinase C) inhibitory activities in vitro.
Lapatinib, a dual tyrosine kinase inhibitor of both EGFR and HER2/erbB2, is thought to react with the ATP binding site of protein kinases, competing with the ATP substrate inhibiting EGFR/HER2 autophosphorylation through this competition.
Gene circuits are implemented by inserting the transcription factor (TF) binding site of regulatory gene product, i.e. the binding site of protein produced by regulatory gene, to the promoter region of regulated gene by the techniques of transfection and transformation [ 7, 14].
The compound was designed in 1996 by using the known structure of the ATP binding site of protein kinases, and early biochemical screening showed STI571 to be a potent inhibitor of BCR ABL TK (IC50: 0.025 μ M in vitro for substrate phosphorylation).
All four types of disease variants are enriched within DNA binding sites of protein by ChIP-seq, DNase I hypersensitive sites by DNase-seq, and open chromatin regions by FAIRE-seq.
Similar percentages of human genome, 11.76%, 11.97% and 13.87%, comprise DNA binding sites of protein by ChIP-seq and open chromatin regions by DNase-seq and FAIRE-seq, respectively.
A superposition of CylM with the CDK2-substrate peptide bound structure (Bao et al., 2011) reveals that the LanM-specific KA domain occludes the canonical peptide binding sites of protein and lipid kinases.
Such cavities are putative binding sites of proteins for ligands.
Interactions in the model are based on activities of individual phospho-epitopes and binding sites of proteins involved in G2/M.
The rational/structure-based design and/or combinatorial development of molecules capable of structurally and functionally mimicking the binding sites of proteins represents a promising strategy for the exploration and understanding of protein structure and function.
