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The binding site of each subunit has a distinct, evolutionarily conserved pattern of polar and hydrophobic residues specifying recognition of discrete substrate motifs.
In addition, for both enzymes we have found evidence indicating that differences in shape and accessibility exist between the substrate binding site of each monomer which could be modulating the binding affinity of non-covalent molecules.
In docking-based IVS, a given small molecule is docked to the binding site of each protein in a target database through a docking engine.
We used these indices to translate the putative binding site of each OR protein into a 66-dimensional vector.
Using GITTAR [23] we calculated the probability of being a binding site of each TF given the background and ChIP-chip ratio.
D1 regions, which contain prothrombin-activating and -binding domains and are presumed to be the binding site of each type-specific antiserum, were classified into twelve clusters having more than 90% nucleotide identities, resulting to create two novel SC types, XI and XII, in addition to extant 10 types.
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Ideally one micelle could bind to one HA trimer, where the receptor binding sites of each monomer have a distance of 4 nm.
Percent fenvalerate removal diminished with increasing dye concentration because of nearly complete coverage of the binding sites of each CMNT at high fenvalerate concentrations.
This diagram shows the process by which the ligands and binding sites of each PDB/PDB_REDO model are classified based on how well the model fits the ED.
The proportion of significantly conserved binding sites among all the binding sites of each transcription factor is shown in supplementary Tables S5 and S6.
We repeated this GC-matched background sampling procedure 100 times and calculated mean numbers of predicted binding sites of each transcription factor along with their standard deviations.
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