Sentence examples for binding site of compound from inspiring English sources

Hence, the location of the binding site of compound 5 c was investigated by ITC experiments.

The expected binding site of compound 8 was successfully confirmed by demonstrating chemical shifts in the H N HSQC spectra for residues at the pVHL-HIF-1α interface as a result of compound titration.

The binding site of compounds 32 and 34 was mapped to palm pocket-I (PP-I) of NS5B.

Molecular docking studies for the compound 4l have also been executed by Sybyl X-2.1 in which it reveals the binding site of the compound 4l with topo IIα DNA cleavage site where etoposide was situated.

Comparison of the binding site of the compound called '1t' in the CXCR4 crystal structure (Wu et al., 2010) to the predicted binding site of Cp#3 in CXCR3 shows that the two compounds bind in similar locations in their respective receptors.

In this study, we set out to elucidate the binding site of both compounds within the CXCR3 structure.

Nevertheless, identification of the molecular target and the precise binding site of ELN compounds may provide important progress towards the rational development of APP-selective γ-secretase inhibitors.

In particular, the multitude of structurally unrelated chemical activators for TRPM3 raises important questions about the nature of the binding site of these compounds, their mode of action and their potential interaction.

Our predicted druggable site overlaps with the binding site of the halogen compounds, suggesting the opportunities in developing druggable small molecules to stabilize p53.

In addition, predicting the effect of the subtle differences in the kinase binding sites on compound affinity remains a challenge.

All the compounds were observed to accept analogous conformations with similar binding mode around the binding site of urease and these compounds were found to interact with nickel metal ions and the hotspot binding pocket residues (His137, His138, Ala169, KCX219, Asp362, Ala366 etc).