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This region was previously identified as the binding site of another β clamp binding protein, the δ subunit of the γ complex.
Recognition of regions on the surface of one protein, that are similar to a binding site of another is crucial for the prediction of molecular interactions and for functional classifications.
These were found to consist of adjacent protomers engaging the interdomain linker of one molecule in the substrate binding site of another, attenuating the chaperone function of oligomeric BiP.
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Molecular docking were carried out to visualize the binding site of AMA to BSA.
The FOXP3 rs2232365 polymorphism is located within a putative DNA-binding site of another transcription factor, GATA-3, that directly regulates FOXP3 expression, in addition to controlling Treg cell function via interaction with the regulatory regions of the FOXP3 locus.
Generally, HAs are directed to the Fc part (anti-isotypical interference, such as rheumatoid factor), while antiidiotypical interfering antibodies bind to the highly variable Fab portion of the molecule (an antiidiotypical antibody is directed towards the antigen-binding site of another antibody; the antigen binding site of this antibody can be similar in structure to the original antigen).
In addition, the BubR1 binding site on B56 is far from the B56 binding site of shugoshin, another kinetochore PP2A-binding protein, and thus BubR1 and shugoshin can potentially interact with PP2A-B56 simultaneously.
Docking model and pull-down assay showed that AXT directly binds to the DNA binding site of STAT3.
However, the binding site of CALA shows surprising similarity to another lipase, Candida rugosa lipase (CRL).
We previously developed PAI-1-specific RNA aptamers that bind to (or in the vicinity of) the vitronectin binding site of PAI-1.
Structural representation showing the binding site of the inhibitors.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com