Sentence examples for binding site occupied by from inspiring English sources

As expected, the binding site occupied by R6G in the QacR(E120Q -R6G E120Q -R6Gwastructureal to that in the wasQacR-R6G structure, widenticalame protoin-drug inthatctinns including the charge complementation of this cation by E90 (Figure 3C and Table S2).

This, along with the protein targets identified herein, is suggestive that the pyrazolone binding site differs from the substrate binding site occupied by MG132.

To assess whether the binding site occupied by ML352 is kinetically independent of that occupied by HC-3, we pursued [H]HC-3 binding inhibition studies using membranes from HEK hCHT cells.

Indeed, the binding site occupied by MG in both the QacR(E57Q −MG and QacR(E58Q)−MG structures was found to be identical to that in the wt QacR−MG structure with the same protein−drug interactions being made.

This suggests parallels in the mechanism in CobR to these flavin reductases where, in the cell, CobR has the potential to exist with each binding site occupied by a flavin and an NADH molecule.

The recapitulation of the binding site occupied by 8 when it is part of the Hyp-containing inhibitors confidently reinforces it as a true fragment hit for this PPI and is consistent with the previously observed displacement by the 19-mer HIF-1α peptide.

This complex either decays into the original enzyme EE and a product molecule or else it can reversibly bind to another substrate molecule leading to a second complex SEES with both binding sites occupied by substrate molecules.

Then, the cryo-EM density is gradually sliced from top to bottom, revealing the orthosteric binding sites occupied by GABA and the benzodiazepine site occupied by alprazolam.

To account for the observation that more than one B particle can be accommodated per binding site, we adopted a reaction-type model of sequential random binding events that relates the fractions of binding sites occupied by j-1 and j particles.

For each PWM score class we compute the fraction of binding sites occupied by more than 5 ChIP-seq tags within 100bp distance to the predicted binding site.

And the binding sites occupied by STAT1 in vivo upon IFN-γ stimulation do not diverge between repetitive or non-repetitive genomic loci.