Sentence examples for binding site occupancy by from inspiring English sources
The method of Baltz and colleagues has also been applied to MCF7 cells [ 105], allowing observation of overall differences in binding site occupancy by RBPs between cell types.
This finding suggests a dual-layered mechanism of transcriptional regulation, comprising both a continuum of binding-site occupancy by each PIF and a superimposed layer of local regulation that acts differentially on each PIF, to modulate its intrinsic transcriptional activation capacity at each site, in a quantitative pattern that varies between the individual PIFs from gene to gene.
The model comprises the response functions of cis-regulatory modules to their transcription factor inputs, by incorporating binding site occupancy and its dependence on biologically measurable quantities.
In others the effects are exerted by binding at distal sites that rely on flexibility within the protein's architecture to communicate binding site occupancy to the catalytic center.
A more complete model would include the dynamics of mRNA and binding site occupancy.
Thus, the sampling method provided a reliable estimation of the binding site occupancy, since several random groups of predicted sites did not differ markedly in their protein occupancy.
Moreover, they suggest that Ras-signaling-induced phosphorylation of Sam68 interferes with binding of Sam68 to RNA, and may thus affect splice site occupancy by U2AF65.
Our data suggest that Sam68 can affect splice site occupancy by U2AF in signal-dependent splicing.
The latter finding led to the discovery that the PT is regulated by quinones [38], possibly through a specific binding site whose occupancy affects the open-closed transitions depending on the bound species [39].
Consequently, the occupancy of any binding site by a certain TF can be raised by raising TF concentration.
However, the use of prazosin as a pharmacological chaperone for the rescue of FLAG-α1b-adrenoceptor TMI-TMIV-eYFP to the cell surface implies the occupancy of the receptor binding site by this antagonist.
