Sentence examples for binding site may provide from inspiring English sources
Although carboxylate containing compounds are likely to be prevalent among APE1 inhibitors, our screening results suggest that alternate interactions in the binding site may provide additional opportunities for the design of potent and selective endonuclease inhibitors.
However, negative cooperative interactions between the 2 orthosteric β1-adrenoceptor binding sites may provide an explanation of the lower affinity observed for the secondary β1-adrenoceptor protomer, if indeed this occurs as a dimer (23).
Conserved structural elements colored as in panel A. DOI: http://dx.doi.org/10.7554/eLife.07646.012 Finally, we suggest that understanding the t1-binding site may provide new inroads for development of novel anti-miR oligonucleotides (van Rooij and Kauppinen, 2014).
The construction of a mutant that lacks the XPB-binding site may provide a unique opportunity to identify the factors present in these progenitors whose XPB-mediated expression supports leukemic expansion.
The KcsA binding site may thus provide sufficient structural conservation to provide useful insight into the QA binding site in Kv-type potassium channels.
The finding that the combination of two colchicine-domain binders can act synergistically, suggests that such drug combinations, which would not normally be considered due to the similar mechanism of action and identical binding sites may nevertheless provide therapeutic benefit in cancer therapy.
A lost binding site may have been replaced with a new, species-specific binding site - i.e. binding site turnover.
Placing a fluorophore too close to the binding site may disrupt binding, and fluorophores too far away from the binding site may not result in fluorescence changes.
In these cases, the detection of binding-site similarities may provide useful functional information complementary to those of existing methods.
We provide evidence that the evolution of miRNA binding sites may play a role in evolutionary diversification.
Each of these hotspot regions provides a genomic scenario, where up to seven LXR binding sites may explain the regulation of up to eleven T09 target genes.
