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The arrangement of opposite charges within the binding site may play an important role in the recognition and orientation of peptides.
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We provide evidence that the evolution of miRNA binding sites may play a role in evolutionary diversification.
A conserved C/EBP α binding sequence was identified in the core promoter region of the FTO gene, suggesting that the binding sites may play important roles in regulating the expression of FTO gene.
Presumably that is due to compensation by nidogen-2 which is in contrast to nidogen-1 retained within the BM, implying alternative binding sites [ 115], while in addition the presence of laminins with a γ3 chain, harboring respective binding sites, may play a role as well.
Furthermore, some other transcriptional factor binding sites may also play key roles in regulating certain DPGs.
These observations suggest that binding site turnover may play an important role in SP1 binding site evolution.
This study presents evidence for a possible non-cholinergic binding site that may play a role in the mechanism of immunomodulation by nicotine.
Molecular modeling study was used to predict the optimal conformation in the NNRTI binding site, which may play a guiding role in further rational optimization.
A lost binding site may have been replaced with a new, species-specific binding site - i.e. binding site turnover.
Placing a fluorophore too close to the binding site may disrupt binding, and fluorophores too far away from the binding site may not result in fluorescence changes.
Interestingly, Alu repeats contain B-box sequences and thus represent a large fraction of potential TFIIIC-binding sites that may play a role in genome organization.
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CEO of Professional Science Editing for Scientists @ prosciediting.com