Sentence examples for binding site may disrupt from inspiring English sources

Placing a fluorophore too close to the binding site may disrupt binding, and fluorophores too far away from the binding site may not result in fluorescence changes.

These cellular mechanisms are orchestrated by transcriptional regulators; therefore changes in the methylation status of their binding sites may disrupt those processes thus contributing to oncogenesis.

Alternatively, mutations such as H115Y and S111R, which directly interfere with the HIFα-hydroxyproline-binding site, may disrupt pVHL's ability to target HIFα for ubiquitination and degradation without destabilizing the entire VCB complex; these mutations may be associated with a low risk of PCC.

For instance, a mutated splice site may disrupt an authentic exon-intron boundary and thus change the binding site of the spliceosome, which results in an aberrant splicing.

A lost binding site may have been replaced with a new, species-specific binding site - i.e. binding site turnover.

To assess whether at the inversion breakpoints crucial factor binding sites may have been disrupted, we made another series of inversion constructs (Fig. 2A) called Flip49 and Flip49+REP3A.

Therefore, true binding sites may have SNPs less frequently than the non-binding sites.

These data suggest that additional binding sites may exist.

Not all binding sites may evolve under the same constraints.

miRNA binding sites may correspond to 3 open reading frames.

Since no presumptions about localization of binding sites prior to comparison are used, ProBiS may detect new binding sites and suggest ligands that these binding sites may accommodate.