Sentence examples for binding site may block from inspiring English sources
Surface features of the CRD near to the binding site may block binding of some ligands, particularly those with fixed geometry such as the Lewisx structure, rather than enhance binding through favorable interactions.
Endogenous peroxidase activity was used to block the non-specific binding sites.
As a result, blocking one binding site may also affect the function of the other binding site.
The structural data from X-ray crystallography do not preclude the possibility that at higher temperatures the RNA-binding site may be blocked by other regions of the protein (such as the BC loop), but this seems unlikely since these regions would be highly flexible and not likely to pose a strong barrier to binding.
A lost binding site may have been replaced with a new, species-specific binding site - i.e. binding site turnover.
In addition, the calcium or apatite binding sites may tentatively mediate inhibition by binding onto the growing sites of the nascent crystals and blocking further mineralization.
The increase in binding affinity at lower pH was greater for the Ubx optimal binding site than for other DNA binding sites, indicating that subtle sequence alterations in DNA binding sites may influence pH-dependent behavior.
Therefore, true binding sites may have SNPs less frequently than the non-binding sites.
The methyl-CpG-binding protein MeCP2 has been reported to bind to methylated CpG motifs [30] in CRE sites, which may block binding of other factors.
Such binding may block the attachment of elongation factor G and thereby prevent the translocation of peptidyl-tRNAs from the ribosomal A-site to the P-site.
Ena/Vasp and Clip-170 have been described to physically interact with the FH2 domain of Dia. - Although it has not been addressed, if and how binding of Ena/Vasp or Clip-170 interferes with nucleation and elongation and barbed end binding, it is attractive to speculate that binding to the FH2 domain may block sites important for the catalytic mechanism and suppress one or more of these activities.
