First, although in vitro DNA-binding studies suggest there is a flexibility in the Su(H) binding site, like the bHLH E-box, comparative analysis shows that within any one the Su(H) sites there is no sequence flexibility.
The results indicate that from a structural perspective around 75% of the kinome have binding site characteristics that should allow the design of drug-like compounds.
Sakuntabhai and colleagues also presented evidence that the CD209 -336G allele disrupts a potential SP-1-like transcription factor binding site and that this allele is associated with lower CD209 expression in vitro than the ancestral -336A variant [32].
For polymorphic SINEs, the binding site that was most statistically enriched (P = 1e-1283) was that previously reported to be bound by BORIS, a CTCF paralogue that binds a CTCF-like binding site (Pugacheva et al. 2010).
In addition, the co-expressed chloroplast genes with "ABRE-like binding site motifs" suggest that XacPNP participates in the drought response, presumably affecting water and/or ion movements in the host.
This drug destabilizes microtubules by interacting with a binding site that does not overlap with those of known microtubule-destabilizing agents like vincristine or colchicine [ 137, 138].
The binding site of Ficolin-3 to ligands is through the fibrinogen-like domain and the crystal structure of Ficolin-3 has shown that a calcium-binding site is located in the vicinity of the binding site, suggesting that calcium might be required for Ficolin-3 binding to its ligand [26].
Known as a "key-to-lock" technology, molecular imprinting provides a promising perspective by helping create in a straightforward manner binding sites that possess enzyme-like catalytic ability with but higher stability.
The development of cavity-like binding sites that recognize haptens has been reported for a number of species including: human [ 21], mouse [ 22], llama [ 23], and rabbit [ 24].
Like mannose-binding protein, MGL has a monosaccharide-specific binding site that interacts with a simple epitope, which is characteristic of nonself oligosaccharides.
