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The binding site is very highly conserved.
The lectin binding site is very often a shallow groove or a pocket displayed at the protein surface.
Interestingly, this binding site is very close to the end of the coding region of IME4, an inducer of meiosis that is expressed in diploid cells [ 38].
The main result found by the authors is that the binding site is very rigid and pre-organized in the presence of a single magnesium ion.
The DREF binding site is very similar to the BEAF-32 binding site and although DREF might be involved in dosage compensation it is possible that increased BEAF-32 recruitment is the true case of the effects observed by [ 49].
The co-crystal structure of SMARCA3 with this complex shows that the binding site is very similar to that of AHNAK peptide: two SMARCA3 peptides symmetrically bind to the S100A10-AnxA2 22 complex at the 'back' of S100A10 reaching into a small hydrophobic cavity created by the 'C-terminal' of AnxA2 peptide and helix IV(IV′) (Oh et al., 2013).
Similar(52)
Moreover, when the two models were overlaid, the orientation of erlotinib and the conformation of its binding site were very similar in active (cyan) and inactive (yellow) EGFR-TKD models.
The performance of the different ChIP-seq methods at detecting high confidence NRSF binding sites is very similar; the percentage of motif-containing peaks varied by less than 3% with the exception of PeakSeq and HPeak.
Currently our knowledge of the TFs and their binding sites is very limited.
The Foxg1 consensus-binding site is very similar to the Foxa2-binding motif (Additional file 5: Figure S2b), and likely to bind to the same motif [ 56].
These EWS-FLI1 binding sites were very frequently located far away from any transcription unit, with a mean distance to transcription start sites of 242 Kb and up to 3 Mb.
More suggestions(15)
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