Sentence examples for binding site is that from inspiring English sources
The most highly conserved binding site is that of the HIV-1 protease, likely due to the large volume and enclosed shape of the catalytic binding site that enables consistent identification by fpocket and robust detection of similarity by SiteHopper, respectively.
A third explanation for increased observation of SNPs in the binding sites is that SNPs are involved in altering gene expression during evolution through affecting the binding site sequences.
A further possible explanation for H3Y41ph peaks that do not overlap STAT5 binding sites is that H3Y41ph is laid down by at least one other kinase (Dawson et al., 2009; Griffiths et al., 2011), which may function independently of STATs.
A further interesting comparison of convergent sugar-binding sites is that, within fold families, there are often common mechanisms of binding to a core monosaccharide in a primary binding site, but diversity in binding of oligosaccharide and glycoconjugate ligands is achieved through extended and secondary binding sites that are unique to individual members of the family.
Another advantage of disordered filaments as binding sites is that only a little protein is needed to fill a lot of volume a very economical way of having a small amount of protein generate a huge binding site.
The significance of the larger BtMinpp ligand-binding site is that it may permit alternate substrate binding modes.
Important considerations for designing metal-binding sites are that packing interactions in the binding site should be carefully considered to avoid costly reorganization energies and binding to the unfolded stable should be destabilized (negative design).
Another feature of the protein metal-binding sites is that the metal ions are often bound to hydrophilic ligands, surrounded by hydrophobic shell or situated in deep hydrophobic cavity [53].
Similarly, the Le epitope binding site is missing in NV that does not bind the seLe antigen.
From each computational algorithm incorporated by ExprTarget, a parameter that quantifies the confidence of each binding site is used so that the final model is target-site based.
However, it is noteworthy that the binding site is exactly the same as that observed for the Dpy30C dimer (CD) interacting with the Bre2DBM peptide.
