Sentence examples for binding site is lost from inspiring English sources

When its cognate binding site is lost, the gene is reactivated [ 54].

As the low‐affinity binding site is lost in gephyrin‐G375D, we conclude that Gly375 is likely an integral part of this binding site.

Presumably, the integrity of the substrate binding site is lost when these residues are mutated leading to lower affinity for substrate.

Here we defined turnover as a case where a mouse binding site is lost at the corresponding region in human, but compensated by a human-specific site within 10 kb of the location of the lost site in human.

At a single nucleotide position within the target region, we let the birth rate represent the probability (per year) that a new binding site appears when no binding site is present and death rate represent the probability per year that an existing binding site is lost.

By a proteolytic cleavage of the C-terminal part of the native molecule some components of the citrate binding site are lost, as well as a motif responsible for the inhibition by ATP (supplemental Fig. S1).

As reported by [ 45] (their Figure six), the first Lef1 binding site is found in all tetrapods that were investigated, whereas the second Lef1 binding site was lost (or never gained) in Xenopus frog.

At the Dio1 gene for example, two HNF4A binding sites were lost in the mutant, but a third was unchanged.

In contrast, more than 3,000 LMO2 binding sites were lost, mainly outside the regions bound by RUNX1/ ETO and RUNX1.

This loss of protein function might disconnect the extra-cellular matrix from the cytoskeleton as these binding sites are lost.

However, in aged human skin dermis, collagen fibril binding sites are lost and mechanical resistance to traction forces is reduced due to fragmentation.