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To investigate this mode for transcription inhibition, we have employed a model system in which a PNA binding site is localized between the T3 and T7 phage RNA polymerase promoters, which respectively assume the roles of primary and secondary promoters.
The miR-224 binding site is localized between 518 to 524 bp of the PHLPP1 3′-UTR (a total of 1002 bp long) or between 3562 to 3568 bp of the PHLPP2 3′-UTR (3941 bp long).
However, the mediator binding site is localized at the C-terminal part of Gli3 [17] and the Gli3-PHS like repressor that is generated in vivo is not likely to bind mediator, but may exert its repressor function by an independent mechanism.
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The RyR2 binding site was localized to a highly conserved 150-amino acid residue region.
Only one binding event – a ChIP-seq Nanog binding site – was localized directly at the transcription start site, for TU4.
F256, N257 and three of the residues forming the Ca2 + binding site are localized in the I J loop.
However, in an in vitro binding assay in which regions of recombinant PTPμ were expressed [ 17], the homophilic binding site was localized to the immunoglobulin (Ig -like domaIg -like
This finding is compatible with previous observations that the PA-binding site is localized to the extreme N-terminus of PB1 [28], [28].
Given, for example, that the Cav3-binding site is localized to the lid region makes it likely that ligand binding will have an immediate impact on the Cav3 Popdc1 interaction.
Here we show that ETS transcription factors are novel regulators of MCM4 origin, whose binding sites are localized between two divergently transcribing MCM4 and PRKDC genes.
These results suggest that GLU A binding sites are localized mainly on the dentate granule cells, whereas GLU B binding sites are localized, in part, on the perforant path fibers, but not on granule cells.
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