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While binding of the Da dimer to the E-box site within the composite Ey2 binding site is important, it is possible that binding of the Da dimer with the Ey PD may interfere the Ey PD interaction with the Ey HD and thus contribute to the increased Ey PD-dependent function.
It is known that this binding site is important for SMN exon 7 processing [33].
Determining the binding site is important for identifying novel compounds that can disrupt HKII binding to VDAC.
These results suggest that the TCF consensus binding site is important for the formation of a protein complex.
Connor and Liao (2008) showed that in addition to the expression of a feedback-resistant leucine operon, a synthetic ribosomal binding site is important for the efficient expression of the operon.
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According to a previous study from our laboratory, NF-κB binding site was important for medaka β-defensin response to LPS [19].
Thus, the accessibility of their DNA binding sites is important in maintaining pluripotency.
These data suggest that the region −116 to + 36, which includes evolutionarily conserved predicted transcription factor binding sites, is important for basal transcription of ALMS1.
The continuous collar of binding sites is important because substrate binding to three or more adjacent apical domains is essential for productive folding of stringent (strictly GroEL-GroES dependent) substrates (Farr et al., 2000).
Therefore, the NF-κB-binding site is important in CCN4-induced IL-6 production.
We next asked whether the spacing between the two core binding sites was important for FOXP3 DNA binding.
More suggestions(14)
binding domain is important
binding specificity is important
binding site is small
binding strength is important
binding site is evident
binding mode is important
binding site is unexpected
binding partner is important
binding mechanism is important
binding information is important
binding epitope is important
binding site is different
binding interaction is important
binding site is likely
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