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Exact(14)
BBL becomes ordered on biotin binding and then adenylate binding site is formed in EcBirA.
Even though this binding site is formed by residues of helices H3, H4 and H12, its conformation is mainly determined by the H12 position.
The OX1 OxB binding site is formed by TM3 and TM5 7.
The secondary binding site is formed by the same region of ILY (the β2-β3 loop in D4) interacting with CD59 from a neighboring unit cell.
However, as the binding site is formed by a hinge region between two domains that undergo induced-fit movement during the catalytic cycle, such substitutions may not be tolerated.
Therefore due to the p47 phox binding site is formed by two independent domains (SH3A and SH3B), the ligands can recognize different regions of the two SH3 surfaces to bind and maintain p47 phox in an autoinhibited conformation.
Similar(46)
Uniquely among the family of glutamate ionotropic receptors, NMDA receptors require both glutamate and glycine (a co-agonist) to bind to the receptor for channel activation to occur with the glycine binding site being formed by the S1 and S2 domains of the GluN1 subunit and glutamate binding site being formed from the homologous regions on the GluN2 subunit.
Finally, a third method of incorporating pharmacophores into virtual screening is to add constraints to the docking run to ensure that certain interactions between the ligands and the target binding site are formed.
Furthermore, we also showed that the ADP binding site was formed by K22, R79 and R279 residues which associate with the phosphate moieties of ADP.
The hydrogen bonds with GlcNAc were impaired and a new binding site was formed between Gly250 and Asn254, which appeared to stabilize the complex with GlcNAc, albeit with relatively weaker binding.
The binding site was formed by 3 LysM motifs.
More suggestions(15)
binding unit is formed
binding site is shifted
binding groove is formed
binding site is outlined
binding site is increased
binding site is buried
binding cavity is formed
binding site is composed
binding site is conserved
binding pocket is formed
binding site is blanked
binding site is provided
binding site is blocked
binding geometry is formed
binding site is embraced
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