Sentence examples for binding site is essential from inspiring English sources
These findings suggest that the NF-κB binding site is essential to PP2-mediated rescue of activation of the IL-8 promoter in Thy-1+ MEFs.
Some historical studies hold that mutation of the ATP binding site (K270A) abolishes the antiviral function of RIG-I; in other words, the ATP binding site is essential [ 24].
To determine whether the Ser262 tau-MT binding site is essential for Wnt5a evoked axon outgrowth and guidance, we transfected cortical neurons with a tau construct mutated at Ser262.
CaMKII has been shown to be the major mammalian kinase to phosphorylate tau at Ser262 (Sironi et al., 1998; Bennecib et al., 2001) and we show that phosphorylation of this tau MT binding site is essential for Wnt5a induced axon outgrowth through MT reorganization.
For binding of HuR, presence of the consensus HuR binding site was essential but not sufficient: we could not detect binding of HuR to any of the transcripts lacking this site; however, of the eight transcripts containing this site, HuR bound to EfnA2, EfnB2, EphA2, EphA4, and EphA6 but not to EfnA1, EfnB3, and EphB1.
The results of the present studying validated that the pharmacophoric model with four binding sites is essential for anticonvulsant activity.
Membranes are particularly useful for the separation of large protein molecules (Mw > 250 kDa) where better access to the binding sites is essential (Endres et al., 2003).
Likewise, kallistatin's heparin-binding site is essential for blocking HMGB1-induced inflammatory gene expression in endothelial cells [ 25].
AP-2 acts as a negative regulator in extrahepatic tissues but promotes liver-specific rSAA1 expression [28]; in addition, a proximal AP-2 site in combination with the NF-κB-binding site is essential for rSAA1 promoter activity [25].
The binding of ATP to the transporter's nucleotide-binding site is essential for substrate transport, and the hydrolysis of ATP by P-gp ATPase is critical for restoring the transporter to its active conformational state (Rosenberg et al, 2001).
