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However, the second binding site is absent in other transporters (e.g., TpTroA), and therefore its exact biological function remains unclear [33].
The mRNA is designed so that the morpholino binding site is absent and is coinjected with the morpholino or injected separately in a second injection.
This binding site is absent from one of the winter crane fly species, Paracladura, but present in the other, Trichocera (Fig. 2 A ).
From ORA's prediction it could be concluded that this binding site is absent in S288c since this strain lacks the terminal part of the transcript.
Notably the resonance at − 0.14 ppm that we have attributed to the POPG bound to the non-annular binding site is absent in the spectra of the three mutants.
Similar(55)
A drop in activity was observed when either the TATA-box or the NF-ĸB binding site was absent.
NF-Kappa NF-Kappa Bsites are abindingf the promoter region A1, which activity isites increared by Nter-142Q (Supplementabsent. S1 and Fig. 3).
This is ligand-based drug design and has been most often applied when structural information regarding the target proteins and their binding sites are absent.
Similarly, when the CTCF binding sites are absent on the maternal allele, the enhancers have unlimited access to the whole region, showing that CTCF is necessary for enhancer-blocking activity.
By searching orthologous intergenic sequences for a small set of a carefully defined transcription factor binding sites as well as for a larger set of sites defined by chromatin immunoprecipitation experiments in S. cerevisiae, we show that a substantial fraction of binding sites are absent in distantly related species and so cannot be explained by binding site turnover.
Examination of the first site, between trnE and trnF, where primary transcripts labeled A and D in Figure 1 meet, show that this binding site is not completely conserved across Diptera and is absent from the Mecoptera (Fig. 2 A ).
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