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Exact(28)
The ATP binding site is a narrow channel located at the hinge between the domains.
The crystallographic analysis revealed that the antigen binding site is a rather shallow binding pocket, and residues from all six complementary determining regions of the antibody contact all sugar residues.
In EcBirA, biotin binding site is a hydrophobic groove with hydrogen binding partners Ser89 and Thr90 pre- positioned to accept biotin (21).
P1 in the Aq binding site is a medium-sized and relatively lipophilic pocket that accommodates Ile260 of the non-modified 1, as shown in Figure 2. Analysis of the coefficient values from the PLS regression model based on the Aq binding data clearly showed that Ile was the preferred amino acid in p260 (upper plot in Figure 6).
The ATP binding site is a narrow, hydrophobic pocket located between the two lobes; its floor is formed by a C-terminal β-sheet, and its roof is formed by the G-loop, which fastens the γ-phosphate of ATP and serves as a regulatory flap above the ATP-binding site [45], [51], [53] [55].
Another binding site is a bulky basic group, including an α-amino group.
Similar(32)
The presence of such similar halide binding sites in non-halogenases could indicate that this halide binding site is an artifact of crystallization.
This result indicated that the common binding site was a nonclassical membrane estrogen receptor.
Identification of transcription factor binding sites is a vital task in contemporary biology, since it helps researchers to comprehend the regulatory mechanism of gene expression.
Previous MD results [33, 52] concluded, that finding prerequisite binding sites is a substantial advantage of the MD simulations.
This is not surprising, since the complexity of the metal-containing microenvironment of the binding sites is a well-known phenomenon [29, 38].
More suggestions(19)
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