Sentence examples for binding site including the from inspiring English sources

Notably, we observed that three of the mutated PyrR residues lie in close proximity to the 5-FU binding site, including the amino acid Val178, which is involved in water mediated hydrogen bonding contact with 5-FU.

Allowing a single mismatch yielded a list of 101 genes with a putative ClgR binding site, including the ATPase clpC1 and clgR itself.

The PD contains the PI 3,4,5 P3 catalytic binding site, including the P-loop consisting of the signature HCXXGXXR motif, common with many protein tyrosine phosphatases (PTPs).

X-chromosome-linked agammaglobulinemia (XLA) is an example of a disease where mutations are present in the SH2 domain of the Bruton's tyrosine kinase (BTK), and many of these mutations are located on the pTyr-ligand binding site, including the indispensable arginine of the pTyr-binding pocket as well as BG loop residues [ 16, 173].

We show by peptide-based mapping and site-directed mutagenesis that the VD1 binding site includes the five residues 147NEESL151 and that immunization with a synthetic peptide containing this motif generates antibodies that neutralize VEGF-D.

The fact that inactive Rac1 binds to the N-terminus of Abi1 suggest the possibility that Wave 2 competes with Rac1, since the region containing the Rac1 binding site includes the Wave 2 binding site [32].

This proposed binding site includes the highly conserved HPD motif.

Investigation of neuroendocrine genes has revealed that transcription is regulated via multiple DNA binding sites, including the cyclic AMP response element (CRE).

It is important to note that this deletion removes multiple transcription factor binding sites, including the FUSE binding element known to be required for proper MYC expression [16].

The basic assumption is that many putative binding sites, including the sites of TFexp and of other factors, not just the single best match, may contribute to interaction of this sequence to TFexp.

Specifically, we report the results of virtually screening ∼11,000 diverse fragment-like compounds against a total of 152 protein binding sites, including the training dataset and external dataset studied by Hajduk and coworkers [27].