Sentence examples for binding site in which from inspiring English sources

The second region is the PPant binding site, in which the backbone N-H groups of Ala145 and Gly184 in monomer B form hydrogen bonds to the carbonyl oxygen atom of the β-alanine component of PPant.

Here, we demonstrate that the insulin-induced inhibition of GSK3 and its unique substrate specificity are explained by the existence of a phosphate binding site in which Arg-96 is critical.

Instead we have postulated that in the primary repertoire, all or most antigen receptors have a bipartite binding site, in which diverse CDR3 loops act as a highly antigen specific 'core' whereas other CDRs bind in a largely opportunistic fashion.

In the neuronal culture experiments, we actually used a milder mutant for the third binding site, in which only two of the hydrophobic residues in repeats 11 and 12 were changed to Gln (LF to Q).

This conclusion might explain the functionality of several ABC transporters with one degenerate nucleotide binding site, in which the ATP binding capability of both sites is preserved but hydrolytic activity is present in only one of the sites.

The fastidious binding of these molecules could be easily understood from wire models of the binding site, in which charged and hydrophobic residues were found in appropriate places to interact in a simple manner with the anchor residues of the bound peptides (Wallny et al., 2006).

On the other hand, care has to be taken for large binding sites in which different parts can be occupied by ligands.

The proteins often had binding sites in which multiple interactions can be formed with target molecules by high specific affinities or catalysis activities.

We note that the involvement of miR-15 miRNAs in the elastin feedback loop was not predicted in previous studies [35], [52], and indeed could not have been anticipated based on predictions of miRNA binding sites in which only the 3' UTR is considered.

The worst scenario will occur when weak binding sites have completely opposite supporting data distribution compared to that of strong binding sites, in which case the fitted regression model will predict against the weak binding sites.

As expected, in the subset of binding sites in which no rotamer changes were observed, the Apo-bound and Holo forms show no significant differences in their steric potential for rigid binding sites.