Sentence examples for binding site in human from inspiring English sources
Gast, D. et al. The RGD integrin binding site in human L1-CAM is important for nuclear signaling.
Further studies on the effect of quaternary ammoniums on human ether-à-go-go related gene channel inactivation implied that hydrophobic quaternary ammoniums either with a longer tail group or with a bigger head group than tetraethylammonium permeate the cell membrane to easily access the high-affinity internal binding site in human ether-à-go-go related gene channel and exert stronger blockade.
"Uncommon structural motifs dominate the antigen binding site in human autoantibodies reactive with basement membrane collagen". Molecular immunology 76 (August 2016): 123-133.
It should be also pointed out that recent data provide direct evidence supporting the existence of a second substrate binding site in human IDO [50].
These results support the previous in vitro assay data [13] showing the presence of a CTCF binding site in human 5'HS5 [13].
The interaction of the Sp1 binding site in human resistin gene with Sp1 transcription factor present in U937 cells was assessed by performing EMSA using radio labeled oligonucleotide corresponding to hres Sp1 binding motif (−276 to −295).
The second, weaker binding site in humans seems to be conserved and somewhat more responsive to p53 in mouse.
miR-181 has a consensus binding site in humans, chimpanzee and rhesus macaque but not mice and rats.
Although based on the similarity with the binding site in humans it is unlikely that emetine can be structurally modified to not bind the mammalian system, as demonstrated in the case of dehydroemetine modifications can reduce its cytotoxicity.
This award "funds high risk, high reward approaches to solving complex problems in cancer research that tend to fall outside the scope of other funding opportunities". Nomura's lab is mapping hotspots of binding sites in human proteins that have been traditionally considered "undruggable" and developing novel small molecule drugs that bind to those proteins.
It is reported that quercetin displaces warfarin bound to human serum albumin [26] due to competitive binding and that genistein also shares the binding sites in human serum albumin with warfarin [27].
