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P. falciparum IEs from laboratory strains (Ref. 94) and field isolates (Ref. 70) bind to PECAM1 on endothelial cells and the binding site has been mapped to the first four immunoglobulin-like domains of PECAM1 (Ref. 94).
In addition, a central binding site has been defined18 that was almost identical in all periplasmic-facing structures12,13,14.
Thanks to a recently designed pressurization cell using krypton at high pressure, a new gas binding site has been characterized that reveals an alternate pathway for gaseous ligands.
We have produced a mutant where the serine 35, a residue located at the entrance of the alcohol binding site, has been replaced by a cysteine residue.
Thermodynamic data from isothermal titration calorimetric studies suggest that modification of the interactions in the SH2 binding site has been largely unsuccessful in producing high-affinity inhibitors.
IL-27 has also been shown to induce the activation of NF-κB24,25,30, for which a putative binding site has been identified in the BST-2 promoter21.
This statement is supported by the finding that CadC also forms clusters in a mutant in which the binding site has been relocated to another position within the chromosome.
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Moreover, CadC is still capable of forming clusters even in a mutant in which the CadC-binding site has been moved to another position within the chromosome (Fig. 6d).
Transmittal of conformational changes from the microtubule- to the nucleotide-binding site has been proposed to involve the central β-sheet, which could undergo large structural changes important for force production.
Given that the Drosophila genome has been sequenced [3] and that the SXL-binding site has been well characterized [20], [21], [22], [23], we searched the entire Drosophila genome using a weight matrix corresponding to the SXL-binding site.
Additionally, an LXR (liver X receptor -binding site has been found in the second intreceptor -binding
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