Sentence examples for binding site for small from inspiring English sources
Based on our discovery and hypothesis, further studies should focus on the analysis of crystal structure of reverse transcriptase and explore the possible binding site for small RNA.
The charged surfaces of PrgI responsible for needle assembly also provide a potential binding site for small molecule ligands.
16– 18 Furthermore, modeling and mutagenesis studies confirm that the inner cavity is a binding site for small ionic molecules.
This bending forms the domain's triangular prism shape and it opens a hydrophobic pocket between the sheets, constituting a possible binding site for small molecules.
SAL1 exhibits a classical structure of lipocalins characterized by a fully conserved N-terminal -G-X-W motypical the typical folding pattern of a nine-stranded antiparallel β-barrel forming an internal ligand binding site for small hydrophobic molecules [ 12], despite relatively low sequence similarity [ 13].
Structure-guided mutagenesis studies revealed that the Smo CRD binds to 20(S -OHC in the region that waS -OHCinusly identheied as the binding site foregionl hydrophobic molecules in othat CRDs, formed by the evolutionary conserved helical bundle of the CRD core.
Based on the structure of HIV-1 gp41 binding site for small-molecule inhibitors, optimization of lead 2 resulted in the discovery of a new series of 2,5-dimethyl-3- 5- N-phenylrhodaninyl 2,5-dimethyl-3- 5- N-phenylrhodaninyl 2,5-dimethyl-3- 5- N-phenylrhodaninyl 2,5-dimethyl-3- 5- N-phenylrhodaninyl 2,5-dimethyl-3- 5- N-phenylrhodaninyl 2,5-dimethyl-3- 5- N-phenylrhodaninyl
Furthermore, the interaction partners of each motif were found to be very limited, and, accordingly, the interaction networks of the motifs tend to be small and are much more restricted than the binding sites for small ligand molecules.
Similar methods have been developed for comparing protein binding sites for small molecules [20], [21], and they have been recently reviewed [22].
Splice-donor morpholinos alter premRNA splicing by targeting binding sites for small nuclear ribonucleoproteins (snRNPs) or splicejunctions [ 10, 11].
