Sentence examples for binding site for inactive from inspiring English sources
Both Abi1 isoforms share a binding site for inactive Rac1.
The head module is thought to provide the greatest impact in controlling overall transcription primarily by shifting the transcription machinery from active to inactive state rather than serving as a binding site for other transcriptional regulators.
Importantly, this new binding site for DRV may hint at designs for novel types of antiviral inhibitors that capture the open, inactive conformation of the protease.
The 30 kDa β chain consists of an enzymatically inactive serine protease homology domain (SPH) which corresponds to the secondary HGF binding site for MET.
A switch from this so-called 'DFG-out' (inactive) conformation seen in TrkA, Ror2 and inactive IRK to a 'DFG-in' (active) configuration reverses this inhibition in the active IRK structure, as seen on the left in Figure 3. Like IRK, inactive TrkA also places the side-chain of its DFG motif phenylalanine residue (Phe) into the binding site for the adenine ring to further block ATP binding.
In its inactive state Lyn is phosphorylated at its carboxyl terminus by C-terminal Src kinase (Csk) creating a binding site for its own SH2 domain.
This density may not be realistic in the case of a new protein target, as for instance Cdk2 with its newly identified allosteric binding site, for which the ratio of active/inactive molecules found in the ICCL was less than 1/200, corresponding to about 0.5%%.
