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Structural comparison with other known hot-dog fold proteins locates a putative binding site for an acyl-CoA compound in the Cj0977 protein.
The results demonstrate the presence of a peripheral binding site for an imidazolium group at the rim of the BoNTA active-site cleft.
Both of these codons occur within the same primary sequence context (5′AGAG), raising the possibility that this sequence is a preferential binding site for an exogenous agent involved in bladder carcinogenesis.
Comparing the present structure to those of the homologues Staphylococcus aureus QacR and Escherichia coli TetR leads to the hypothesis that the hydrophobic cavity constitutes a binding site for an as yet unknown ligand that might regulate DNA-binding of EthR.
For example, a binding site for an effector molecule (i.e., a nucleic acid that will affect the activity of a functional nucleic acid) may be required to be complementary to a sequence released in a preceding step.
The c.-151C>A polymorphism is predicted to alter the binding site for an unknown transcription factor (www-bimas.cit.nih.gov/molbio/index.shtml).shtml
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The residues that form the binding site for a given antigen, are selected among the hypervariable residues.
They are comprised of a biosensor that includes the binding site for a small ligand and they respond to association with this ligand by undergoing a conformational change.
The truncated mRNA removed a binding site for a microRNA that negatively controls HMGA2 expression.
The binding site for a single catalytic divalent metal ion, typically magnesium, is embedded within this fold.
In addition, the human GATA-2 promoter has two highly conserved ets sites that resemble the binding site for a recently described ets repressor factor, ERF.
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CEO of Professional Science Editing for Scientists @ prosciediting.com