Motif 1 would therefore be the binding site for a cognate activator, a protein expected to bind both DNA and sigma-54.
In vitro experiments have shown that TR4 binds to the direct repeat (DR) of AGGTCA, which is the consensus binding site for a number of nuclear hormone receptors including estrogen receptor alpha and PPAR.
The truncated mRNA removed a binding site for a microRNA that negatively controls HMGA2 expression.
The binding site for a single catalytic divalent metal ion, typically magnesium, is embedded within this fold.
The residues that form the binding site for a given antigen, are selected among the hypervariable residues.
This is because there can be more than one structural scaffold associated with a ChEMBL family, or more than one binding site for a given receptor family.
It is now shown that a large binding site for a protein antigen (lysozyme) can also be transplanted from mouse to human heavy chain.
They are comprised of a biosensor that includes the binding site for a small ligand and they respond to association with this ligand by undergoing a conformational change.
It was shown previously that the binding site for a small hapten could be grafted from the heavy-chain variable domain of a mouse antibody to that of a human myeloma protein by transplanting the hypervariable loops.
The binding site for a PDZ domain [8] is the last domain of the C-terminus.
The latter was used as a primer binding site for a second round of amplification.
