Binding site turnover, whereby the gain of a redundant binding site enables loss of a previously functional site, is one model by which cis-regulatory sequences can diverge without a concurrent change in function.
The generation of this unique pY1175 binding site enables recruitment of PLCγ1 via its SH2 domains and subsequent phosphorylation on residue Y783.
This step induces long-range remodeling of the RNA to expose a cryptic Rev binding site, enabling rapid assembly of additional Rev proteins into the RNA export complex.
Based on these findings, the internalization and disassembly of E-cadherin adhesive complexes may at a given point along the endocytic route expose the E-cadherin C3G binding site, enabling activation of Rap1, which appears to be a key determinant of E-cadherin recycling and formation of new cell-cell junction complexes [36], [37].
T57R substitution introduced a flexible positively charged residue near the chromophore binding site, enabling electrostatic attraction of BV and its additional shielding from solvent.
Woon, E. C. et al. Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases.
In addition, the identification of cell type specific TR4 binding sites enables future studies of the pathways underlying TR4 action and its possible role in metabolic diseases.
The peculiarity of SERCAs in respect to the other Ca2+-ATPase pumps is to have two Ca2+ binding sites, enabling the existence of a Ca2+/ATP transport stoichiometry of 2.0 [ 54].
ChIP allows unbiased genome-wide coverage of the zebrafish genome to identify Hif-1α binding sites, enabling development of zebrafish as an emergent model organism for research into the hypoxic response in a physiological context [ 41, 42, 46, 52, 68].
Transcription factors are proteins which bind to specific sequences of DNA, called binding sites, enabling and controlling the expression of genes.
