Sentence examples for binding site do not from inspiring English sources

In our original manuscript we reported that mutations (R107E/R109E/R115L) in the Norrin GAG binding site do not affect the ability of Norrin to bind Fz4CRD but do impair the activation of signalling.

Patients presenting with NOTCH1 mutations that remove the Fbw7 binding site do not have Fbw7 mutations upon relapse.

Children with an autosomal dominant defect in IFN-γR1 that causes a deletion in the STAT1 binding site do not develop disease when infected with T. gondii [45].

The key residues in the binding site do not locate in disordered domain (>0.5), which indicates that PKM2 protein expresses a stable binding domain in protein folding.

In addition, our results indicate that the position of genes relative to a CUX1 binding site do not determine whether these genes are regulated by CUX1.

Evaluation of the changes in constant pressure heat capacities during binding suggest that solvent exclusion from the binding site does not account for the dramatic affinity enhancements observed.

This result indicated that no Trp residue of p53 1-63) is located in the interaction site with azurin and therefore suggested that the azurin binding site does not overlap that of MDM2, the protein that plays a crucial role in the p53 regulation.

As shown in Figure 6, all mutant SVOP proteins demonstrated nucleotide binding similar to wild-type SVOP, indicating that the binding site does not depend on these conserved residues.

Although the removal of the PTB binding site did not affect the focal adhesion localization, it partially reduced the RhoGAP activity of DLC1, which attenuated its growth suppressive function.

Transfection experiments with constructs containing F1F2wt or F1F2mut showed that mutation of the F2 binding site did not only abrogate any T3 effect, but also impaired enhancer blocking (Fig. 5E).

Furthermore, mutation of the N-terminal ATP binding site did not alter the catalytic activity of the enzyme, which suggests that either the mutated residue was not essential for N-terminal ATP binding, or ATP binding in the N-half of HKIII does not regulate the activity of the C-half.