Sentence examples for binding site distinct from from inspiring English sources

The peptidyl-prolyl cis/trans isomerase PPIL1 is a component of the human spliceosome and binds to the spliceosomal SKIP protein via a binding site distinct from its active site.

These results suggest that AAL binds to the N-terminal fructosyl valine at a binding site distinct from that of l-fucose.

Or alternatively, does RKIP have another binding site distinct from the pocket?

Notably, mutation of residues I489 and W497 had no effect on binding to HERC2 suggesting a HERC2 binding site distinct from that for FTH1.

In contrast, lack of competition between thioflavin T and the neutral phenothiazine amide derivative (5) with BuChE (Table 1, Figure 4) suggests that this phenothiazine derivative has a binding site distinct from that of thioflavin T (1) on this enzyme.

The TPIMS inhibitors did not prevent binding of As III), indicating noncompetitive binding at a site distinct from the substrate binding site.

Rather than acting directly by blocking the glutamate orthosteric binding site, ADX10059 modulates the activity of the mGluR5 receptor by binding to a site distinct from the glutamate binding site (ie, an allosteric site), and diminishes the intra-cellular signal created when glutamate binds to the receptor.

In addition we reported that polyphosphates such as ATP and triphosphate act as non-substrate heterotrophic activators, binding at a site distinct from the active site and distinct from the peptide activation site [12].

Our docking analyses also explain the inability of CTP to serve as a phosphoryl donor to DCoA as it shows specific and stoichiometric binding at a site distinct from that of ATP (the P-loop).

This finding indicates that compounds from series 2 bind at a site distinct from both substrate-binding sites.

Monoclonal antibody H22 binds to a site distinct from the ligand-binding site, yet effectively triggers Fc γRI-mediated cellular responses (such as phagocytosis, respiratory burst, and ADCC) in the presence of high concentrations of human serum IgG (Guyre et al, 1989; Valerius et al, 1993).