Sentence examples for binding site distant from from inspiring English sources

The ATP-free enzyme revealed a novel binding site distant from the ATP binding site that was not encountered in the ATP bound enzyme.

However, the MAb 17B itself did not block Env-Galcer binding, suggesting that the C1 antibody-induced gp120 conformational changes resulted in alteration in a Galcer binding site distant from the CD4i 17B MAb binding site.Galactosyl ceramide, a glycosphingolipid, has been postulated to be a receptor for the HIV-1 envelope glycoprotein (Env) interaction with mucosal epithelial cells.

Finally, the TF myocyte enhancer factor 2D (MEF2D) was recently shown to regulate the transcription of specific genes within the light mtDNA strand through a binding site distant from the D-loop (She et al. 2011).

Some published SDH crystal structures (eg. PDB: 1E3J) contain a second, structural zinc-binding site distant from the active site catalytic zinc atom; this is not however a universal feature of these enzymes.

As noncompetitive inhibitors, their binding to a site distant from the substrate binding site implies a conformational change that may be regulatory and not linear with substrate binding.

This chapter develops an alternative strategy using a small molecule that covalently modifies C286 at a novel interaction site distant from the BH3-binding groove.

Glu47 and Phe97 are strictly conserved in the Tob/BTG family, but this binding site is distant from the CNOT7 interface.

Location assays have indeed identified that a significant proportion of nuclear receptor binding sites are distant from the regulated genes [43].

In the 25S rRNA secondary structure, the Erb1 and Nop7 binding sites appear distant from the 3′-end of 5.8S and ITS2.

When mapped on to the unbound NiV-G structure, these sites localize to the top of the β-propeller near the HN sialic acid-binding site and distant from the MV-H CD46-binding site.

As the proposed tubulin-binding site is distant from the nucleotide-binding pocket on MCAK (Ogawa et al, 2004), as for all kinesins studied to date, this stabilization likely occurs via an allosteric mechanism rather than a direct interaction of residues from tubulin with the nucleotide-binding site.