From the binding sites discovered in the present study some were previously confirmed to be the important binding sites [ 28- 30] for GATA-3, as mutating them causes complete loss of enhancer activity [ 30].
There were a large number (232) of potential regulatory transcription factor binding sites discovered through in silico studies in the promoter region of ABCB5 including CREB, PAX6, CEBP, and OCT1 and also ABCC1 [ 3].
Analysis of the binding sites discovered by ChIP-seq in ESCs revealed a hexanucleotide consensus ZFP57-binding sequence (TGCCGC), which was highly conserved in 81 of 91 bound loci.
H1.4K26 methylation was the first methylation site discovered in H1.
In addition, for NEDD4-family E3s, a noncovalent ubiquitin binding site was discovered in the HECT domain, which promotes polyubiquitination through poorly understood mechanisms (French et al., 2009; Ogunjimi et al., 2010; Kim et al., 2011; Maspero et al., 2011).
The data set was split into sites discovered before 1994 and sites discovered in 1994 or later.
Several immune-related transcription factor binding sites were discovered in the putative 5′-flanking region.
Given that most of the binding sites were originally discovered in Plasmodium species and also for consistency we anchored the maximum lengths of upstream regions in non- Plasmodium species at 2000 bp as well.
It is in the C-terminal domain of the hPMS2 subunit that a conserved DQHA(X 2E(X)4E heavy metal binding site was discovered [13], [19], [20].
Despite this large range of metal dependencies, several metal-binding sites have been discovered in the most conserved domains of the group II introns, including D5 and D6.
