Sentence examples for binding site determined by from inspiring English sources
Interestingly, this binding mode corresponds to the 6-ECDCA orientation within the rat FXR binding site determined by X-ray crystallography (PDB entry 1osv ) and was also in line with SAR studies on bile alcohols as FXR ligands by Iguchi et al. In both docked ligand orientations, interactions with Arg331 via hydrogen bonds were observed (Fig. 9).
This is consistent with the hydrophobic nature of the binding site determined by mutagenesis.
Promisingly, when the technique is applied to large structures, such as polytene chromosomes, the background can be distinguished from signals of interest if it is not localized to chromosomes or does not coincide with binding sites determined by conventional immunostaining.
The dataset contains 24 CRP binding sites determined by footprinting experiments or sequence similarity to confirmed binding sites; each sequence in the dataset contains one or two sites.
To assess the biological significance of these sites, ligand binding sites determined by Spinelli et al. [ 13] were also mapped on the 3D structure.
The partial overlap between binding sites predicted from an in vitro specificity model and in vivo binding sites determined by ChIP-Seq could be explained in at least two different ways.
The inference of this regulatory network using our algorithm was based on the stress response microarray data under heat shock from 25○C to 37○C, along with 203 TFs and their genomic binding sites determined by ChIP and promoter sequence analysis (see Section 2.3).
The binding site of HGH, determined by the GNM, is depicted in pink and the residues that interact with the HGH binding-site, determined by HotPoint, are in green.
Genomic coordinates of the RNAPII-binding sites, determined by the chromatin integration analysis with paired end-tag sequencing (ChIA-PET) method, were obtained from the saturated libraries constructed for the MCF7 and K562 human cell lines (Li et al. 2012).
The resolution of the DNA-binding sites determined by ChIP-seq was a dramatic improvement on the resolution that was possible using ChIP-chip, because of the higher resolution of high-throughput sequencing compared with oligonucleotide arrays.
