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Therefore, definition of the conformation of this novel extended gp41 membrane proximal region, containing the conserved peptide P1 and the Ca2+ binding site, could help designing an immunogen efficient at inducing neutralizing anti-HIV-1 antibodies.
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The comparison between disorder region and docking site could help the definition of drug efficacy.
Identification of binding sites could facilitate design of DNA binding ligands for capture and detection of insulin and IGF-2.
This fortuitous binding site could later prove to be a useful binding site for other low molecular mass partners.
For this kind of bound structures, binding sites could not be computed directly based on their ligands.
Neither cytotoxicity nor the competition between TCC and testosterone for binding sites could be observed in their studies.
Mutagenesis of the predicted binding sites could show if transcription factors are involved in this function.
Presumably, a ligand-binding site could exist in the groove.
We have observed that docking heparin/heparan sulfate disaccharides to the IL-8 heparin-binding site (Kuschert et al. 1998) does not reveal binding specificity that could help suggesting a most probable binding pose for longer GAGs (data not shown).
In the case of IS200, binding to β could help the transposase to localize to sites with increased amounts of ssDNA, such as replication forks or repair sites, thus increasing the efficiency of the excision or insertion processes.
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