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In both cases, burial of the Cl atom within the binding site could explain the observed sensitivity of the binding affinity to Cl deletion (Table 2).
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Hence, the close proximity of relevant binding sites could explain the dual effect that TREX-2 exerts on Pol II and the CKM.
Specifically we test whether the presence of the YY1 binding sites could be explained by DNA sequence or amino acid motif conservation.
Indeed, a recent analysis of yeast ChIP-Chip data revealed that only 48% of detected transcription factor binding sites could be explained by direct binding and an additional 16% by indirect binding [ 28].
Moreover, the general TFs as well as the Ebox binding site could be pivotal for cellular response to extracellular stimuli and this may explain individual response to treatment or endogenous cytokines [41] [43].
Either visfatin or molecules that fit visfatin's binding site could help control the disease.
This fortuitous binding site could later prove to be a useful binding site for other low molecular mass partners.
Such interactions between elements around the binding sites could easily modulate affinity resulting in autoinhibition.
Presumably, a ligand-binding site could exist in the groove.
Modelling of 12 into the binding sites of 6 and 7 could explain the efficiency of binding.
This binding site can explain why MTs are stabilized by DCX.
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