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Exact(13)
In addition, a completely inactive binding site could be created, for example, by combining the mutations S16R [25] and N118M [15].
Moreover, the general TFs as well as the Ebox binding site could be pivotal for cellular response to extracellular stimuli and this may explain individual response to treatment or endogenous cytokines [41] [43].
The first binding site is unchangeably the carboxyl group of the Asp44, while the second binding site could be either the amino group of Arg45 or the hydroxyl group of Thr43 of the neighboring helix.
Moreover, MRE2 associations with the RY B3-type TF binding site could be found.
In fact, after modeling Lac2 with 1ZPU (Fet3p) as template, no iron binding site could be observed (data not shown).
Finally, in other target regions only a putative binding site could be found with no correlation with any known TSP.
Similar(47)
The cross-linked binding sites could be adsorbed to wheat germ agglutinin and to anion exchange resins.
Neither cytotoxicity nor the competition between TCC and testosterone for binding sites could be observed in their studies.
These observations suggest that an increase in GLU A binding sites could be involved in the induction, but not in the maintenance, of the kindled state.
Whether unidentified SNPs in these binding sites could be involved in driving the association remains to be determined.
On the other hand a match of the same size between residues in two binding sites could be extremely significant.
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