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Unexpectedly, these compounds showed a strongly reduced dissociation rate from the K103N mutant, as compared to the wild type enzyme, suggesting that, once occupied by the drug, the mutated binding site could achieve a more stable interaction with these molecules.
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An examination of the binding sites used to create the PWMs in the TRANSFAC database suggested that introducing gaps into the middle of binding sites could achieve a better alignment for the whole length of the motif.
Either visfatin or molecules that fit visfatin's binding site could help control the disease.
This fortuitous binding site could later prove to be a useful binding site for other low molecular mass partners.
Such interactions between elements around the binding sites could easily modulate affinity resulting in autoinhibition.
Identification of binding sites could facilitate design of DNA binding ligands for capture and detection of insulin and IGF-2.
The cross-linked binding sites could be adsorbed to wheat germ agglutinin and to anion exchange resins.
For this kind of bound structures, binding sites could not be computed directly based on their ligands.
Neither cytotoxicity nor the competition between TCC and testosterone for binding sites could be observed in their studies.
Presumably, a ligand-binding site could exist in the groove.
We had to create a launch site where we could achieve the frequency we needed.
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CEO of Professional Science Editing for Scientists @ prosciediting.com