Sentence examples for binding site conserved also from inspiring English sources
The data obtained reveal some similarities with the human promoter and identify an EGR-1 binding site, conserved also in man and mouse, which is essential for prep1.1 transient expression in zebrafish embryos.
Not only is the area immediately surrounding the UDP-GlcNAc-binding site conserved, but also a path of high sequence conservation is observed from the active site groove, where the O-GlcNAc acceptor peptides are expected to bind, all the way into the TPR repeats, which have been shown to be important for substrate specificity (Lubas and Hanover, 2000; Iyer and Hart, 2003).
The Cx3cr1 promoter was bound by ERG, FLI1, PU.1 and GATA2 (Supplementary Fig S10B) and also contained relevant binding sites conserved between mouse and human (Fig 6B).
Using bioinformatics programs (see Materials and Methods), we identified several putative binding sites conserved between species.
In fact the DN peptide is located very close to the SUFU binding site and is conserved also in Gli2 and Gli3.
The predicted cofactor binding sites are also conserved in most plant KDM3 proteins, suggesting possible H3K9 demethylase function.
Key phosphorylation motifs and binding sites are also conserved, for all the components of the model proposed by Shin et al. [ 48].
All positions are not highly conserved; however the hydrophobic nature of the binding site is conserved.
This report reveals the accommodation of this inserted cysteine residue to maintain the binding site structure and also conserved interactions with the anti-folate RAB-propyl as compared to other DHFR enzymes.
