Sentence examples for binding site composition of from inspiring English sources

The pharmacophore feature arrangement was found to be in good agreement with the binding site composition of the receptor model, but the excluded volumes did not fully reflect the shape of the agonist binding pocket.

The amino acid replacements in SP1 occurred independently at the same position along the bird and eutherian mammal lineages, driving convergent modification of the zf2 structure as well as the binding site composition of its target genes.

To estimate the functional impact of alternative splicing, we predicted changes in domain, motif, and miRNA binding site composition of protein sequences for alternatively regulated exons in stage 1-, 4-, and 4+ tumors [ 17].

The CART method has already been used to classify acetylated or methylated promoters based on the binding site composition of a set of differentially expressed genes [ 35] or to identify relationships between gene expression levels and regulatory motifs in microarray experiments [ 36].

This corresponds to the null hypothesis that the two sequences independently mirror some aspects of the binding site composition of training CRMs, and thus provides a strong baseline to contrast with the homology model where they share sites for the same motifs.

We develop a new method, Regulus, which computes a probabilistic score of similarity based on binding site composition (despite the absence of nucleotide-level sequence alignment), and demonstrate similarity between functionally related CRMs from orthologous loci.

Another aspect of the fusion inhibitor design is analysis of the inhibitor binding site composition and structure-based virtual screening of the putative inhibitors.

A comparison between the N. vit CRM and the Drosophila h_stripe_6+2 CRM indicates an overall similarity of binding site composition (supplementary fig. S4 a, Supplementary Material online).

Here, we compute a probabilistic score of similarity between two sequences x and y in terms of their binding site composition.

In this article, we construct a classification tool that uses the transcription factor binding site motifs composition of some gene promoters to identify new Wnt/β-catenin pathway target genes potentially involved in brain diseases.

Further, the potential roles of halide-binding sites in determining halide selectivity are discussed, as well as whether or not binding-site composition is always a seminal factor for selectivity.