Sentence examples for binding site compared with from inspiring English sources
This may account, at least in part, for the reduced tumour growth in vivo observed for cells expressing β6 that lacks the ERK2 binding site compared with cells expressing wild-type β6 (Ahmed et al, 2002).
However, in contrast to residues on the left of the groove in Figure 4, residues Ile173 and Ala179 in human mincle are shifted away from the binding site compared with the corresponding residues in bovine mincle, which form the right side of the groove.
Luciferase activity was significantly decreased in cells transfected with the PCAF 3'UTR construct with the potential binding site, compared with cells transfected with the empty control vector or the mutant 3'UTR mutant (ACTTT to AGAAT at the putative binding site), suggesting endogenous translational repression of the construct with the PCAF 3'UTR.
As illustrated in Figure 3, the crystal structure shows erlotinib (green in Figure 3A) to be slightly shifted in the binding site compared with its predicted position in the model (yellow in Figure 3A); to the left in the aspect of the Figure by approximately 1 Å.
Finally, bioinformatic analyses displayed that amphioxus ASPP protein could interact with REL protein by conserved binding sites compared with human ASPP2 protein, which seemed to further suggest that the amphioxus ASPP protein involve in innate immunity through NF-кB signaling pathway.
In the larvae, dE2F2 was found to have nearly 4000 binding sites, compared with dE2F1, which only has less than 300 binding sites (Korenjak et al. 2012).
Applications on three human TF ChIP-seq datasets demonstrate the advantage of SeqSite for its higher resolution in pinpointing binding sites compared with existing methods.
Further, T. thermophilius has half the number of binding sites compared with S. cerevisiae and E. coli, indicating its major role on stabilizing the complex.
From divergence data, we have found the presence of an extensive silent nucleotide reduction within miRNA binding sites compared with their flanking regions.
The difference indicates that there is a higher evolutionary pressure to maintain specific PPARγ binding sites compared with specific C/EBPα binding sites for the regulation of adipocyte differentiation and function.
