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In addition, an individual domain or binding site can mediate binding to more than one protein.
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Stover et al [ 25] showed that activated Src can phosphorylate HER1 at Tyr 891 and Tyr 920 in vitro, and that these sites can mediate binding of the SH2 domains of phosphatidyl inositol-3 kinase (PI-3K) and Src itself.
Alternatively, adjacent interaction sites can mediate multivalent binding (3).
Others have shown, however, that p53 half-sites can mediate expression, which involved p53 binding, by remotely interacting with other cis-elements (Menendez et al., 2007).
Our results suggest that Sp1 binding site can function as a distinct TGF-beta responsive element for TGF-beta mediated promoter expression and Sp1 per se can mediate this response.
Each hormone binding site can be divided into an inner and outer binding cavity.
Individual binding sites can be observed via the green FitCons2 class 40 (ρ = 0.43).
These binding sites can be considered as prerequisite or allosteric binding sites.
Two RAP1 binding sites can substitute for the wild-type initiation site.
However, the sequences of binding sites can be very heterogeneous.
Ben-Naim, O. et al. The CCAAT binding factor can mediate interactions between constans-like proteins and DNA.
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