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This binding site can explain why MTs are stabilized by DCX.
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In contrast, the presence of TF binding sites can explain a modest fraction of the conservation of enhancer activity.
Situation by site can explain these differences.
The fact that heparin has an inhibitory effect on the interaction, even though HBD-3 is not the primary binding site, can be explained with the model structures of Vn prepared by two independent research groups28,29.
The limited number of target genes (158) relative to the 339 AR binding sites can be explained by the functional involvement of multiple AR binding sites to regulate the expression of a single gene, as illustrated at the KLK3 locus (Appendix Fig S8).
The extent to which binding site turnover can explain the lack of sequence similarity between distantly related species has been difficult to assess.
The new binding site can be introduced with a minimum of four amino acid changes.
Each hormone binding site can be divided into an inner and outer binding cavity.
In addition, an individual domain or binding site can mediate binding to more than one protein.
In addition, neofunctionalization and subfunctionalization of transcription factor binding sites (TFBSs) can explain the novelty that occurs in the regulatory region of duplicated new genes [ 10- 12].
However, after taking into account the 3'UTR length, the correlation between them is abolished as shown by the partial correlation ρ ω, N | L) = 0.014 (P > 0.05) indicating that correlation between evolutionary rate and the number of shuffled miRNA binding sites can be fully explained by 3'UTR length.
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